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Dr Dhruv Kumar 

Dr. Dhruv Kumar

Professor

Profile Summary

Prof. Dhruv Kumar is a Professor and Cluster Head at the Allied Health Sciences, School of Health Sciences and Technology, UPES, Dehradun. Listed as a top 2% world’s most influential scientist in the area of Oncology and cancer Biology. His academic journey includes a B.Sc. in Chemistry from Banaras Hindu University (BHU), Varanasi, and M.Sc. in Bioinformatics with Distinction from the University of Allahabad (AU), Prayagraj. Dr. Dhruv Kumar further distinguished himself by completing his Ph.D. in Cellular, Molecular, and Industrial Biology from the University of Bologna (UNIBO), Italy, under the highly prestigious fellowship of the Ministry of Human Resource and Development (MHRD), Indo-Italian Government fellowship. Following the completion of his Ph.D., he embarked on a five-year Postdoctoral training at the School of Medicine, University of Kansas Medical Center, Kansas City, USA. Dr. Kumar's research has been dedicated to several cancer types, including Prostate, Pancreatic, Brain, Breast, and Head and Neck Cancer, with a primary focus on unraveling the molecular mechanisms regulating Autophagy and Apoptosis in Cancer Stem Cells. Currently, his laboratory is actively exploring the Autophagy-Metabolic axis in various cancer cells, such as head and neck, oral, breast, and brain, along with investigating the tumor microenvironment for the development of innovative therapeutic approaches. Notably, his research group has made significant contributions to Drug Designing and Drug Repurposing for COVID-19. Dr. Dhruv Kumar's scholarly contributions are evident in his extensive publication record, with articles featured in prestigious journals such as Cancer Research, Cancer Letters, Molecular Cancer, Oncogenesis, Seminars in Cancer Biology, JAMA Otolaryngology, Nature Scientific Reports, and many more. Presently, Dr. Kumar is actively engaged in numerous government-funded projects and is mentoring eight Ph.D. students in the areas of Cancer and Infertility. Beyond his research endeavors, he plays a vital role in teaching courses at the undergraduate (UG), postgraduate (PG), and Ph.D. levels, covering subjects related to Cancer Biology, Stem Cell Biology, Molecular Medicine, and Bioinformatics.

Work Experience

Prof. Dhruv Kumar possesses over 15 years of extensive experience encompassing teaching, research, and administrative roles. His professional journey is outlined as follows:

  • 06/22-Present: Professor & Cluster Head, Allied Health Sciences, School of Health Sciences and Technology, UPES, Dehradun, Uttarakhand, India.
  • 01/21-06/22: Professor & Assistant Director, Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Noida (UP), India.
  • 07/19-12/20: Associate Professor, Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Noida (UP), India.
  • 04/17-07/19: Assistant Professor, Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Noida (UP), India.
  • 08/16-04/17: Assistant Professor, Department of Bioinformatics, SRM University, Delhi-NCR, Sonepat, Haryana, India.
  • 03/12-06/16: Postdoctoral Fellow, School of Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.

In these diverse roles, Prof. Kumar has demonstrated his commitment to academia, contributing significantly to various institutions and enhancing his expertise in the fields of Molecular Medicine, Cancer Biology, Stem Cell Research, and Bioinformatics. His journey includes pivotal positions such as Assistant Professor at SRM University and various roles at Amity University Uttar Pradesh, showcasing his dedication to fostering education and research. Currently serving as a Professor and Cluster Head at UPES, Dehradun, he continues to make substantial contributions to the academic and research landscape.

Research Interests

Prof. Dhruv Kumar boasts an extensive and diverse research portfolio spanning over various critical domains in biomedical science. With over 15 years of profound expertise, he has significantly contributed to Translational Cancer Research, unraveling novel insights that bridge the gap between fundamental discoveries and clinical applications. His dedicated exploration into Cancer Stem Cells has shed light on the molecular intricacies governing these cells. Prof. Kumar's investigations into Cancer Cell Metabolism reveal a nuanced understanding of metabolic alterations in cancer cells, potentially paving the way for innovative therapeutic strategies. Additionally, his work on the Tumor Microenvironment and Tumor Heterogeneity delves into the complex interplay and diversity within cancer populations. His research illuminates the regulatory mechanisms of Autophagy and the role of Exosomes in cancer, offering crucial perspectives on cellular recycling and intercellular communication. Beyond cancer biology, Prof. Kumar's foray into Infertility research explores molecular factors underlying reproductive challenges. Proficient in Genome Editing and NGS Data Analysis, he navigates cutting-edge genetic technologies. His involvement in Drug Repurposing and Drug Discovery underscores an innovative approach to therapeutics, while his recent contributions in COVID-19 research showcase adaptability to contemporary health challenges. Prof. Kumar's overarching mastery in Bioinformatics strategically integrates computational methods, enhancing the comprehensive interpretation of complex biological data.

Teaching Philosophy

Prof. Dhruv Kumar's teaching philosophy is characterized by innovation and inclusivity. He employs a blended teaching approach that seamlessly integrates traditional methods with modern technologies, creating a dynamic and engaging learning environment. One notable aspect is his commitment to discussing cutting-edge research topics, including those recognized with Nobel Prizes, providing students with insights into the forefront of scientific inquiry. Prof. Kumar takes an innovative approach to support slow learners, implementing strategies such as pairing them with a buddy for personalized assistance, arranging expert lectures, fostering group discussions, and emphasizing hands-on training and practical experiences. By tailoring his teaching methods to diverse learning styles and providing additional support mechanisms, Prof. Kumar ensures that every student, regardless of pace, has the opportunity to thrive academically and develop a passion for lifelong learning.

Courses Taught

Prof. Dhruv Kumar has a genuine passion for teaching and a deep commitment to fostering meaningful interactions with students, creating a vibrant and engaging educational environment. With an extensive background in teaching, he has imparted knowledge across various courses at the undergraduate (UG), postgraduate (PG), and doctoral (PhD) levels. Prof. Kumar's enthusiasm for sharing new ideas and insights has been a cornerstone of his teaching approach, inspiring students to explore innovative concepts and contributing to a dynamic and intellectually stimulating learning atmosphere. His continuous dedication to teaching underscores not only his expertise in the subject matter but also his unwavering commitment to nurturing the intellectual growth of students at all levels.

Undergraduate Level (B.Sc.)

  • Basic Bioinformatics (BIOF202)
  • Basics of Cancer (BIOT223)
  • Cell (MMBS104)
  • Metals in Biology (MMBS201)
  • Metabolism (MMBS205)
  • Scientific Writing (HSCC2019)

Postgraduate Level (M.Sc.)

  • Animal Cell Culture & Cell Engineering (SCCB601)
  • Assisted Reproductive Laboratory Procedures (RTCE605)
  • Cancer Pharmacogenomics (SCCB704)
  • Computational Tools in Drug Discovery (MMBS702)
  • Genome Engineering & Editing (SCCB603)
  • OMICS in Biomedical Sciences (SCCB710)
  • Preventive Oncology & Psycho-Oncology (SCCB705)
  • Reproductive & Developmental Biology and Genetics (RTCE604)
  • Topics in Bioinformatics (MMBS610)
  • Trends in Molecular Oncology (SCCB901)
  • Stem Cell Bio II (SCCB 707)
  • Scientific Writing (HSCC8007)
  • Good manufacturing and Lab Practices (HSCC8008)
  • Biosafety and Aseptic Techniques (HSMB 7024)

PhD Level

  • Advances in Molecular Medicine (BIOT 955) at Institute Level
  • Trends in Molecular Oncology (BIOT 953) at Institute Level
  • Research and Publication Ethics” (RPE) –(PHD901) at University Level

Awards and Grants:

Prof. Dhruv Kumar has received several national and international awards and grants as mentioned below.

Awards:

  1. 2020: Research Excellence Award, Institute of Scholars, India
  2. 2019: Senior Scientist Award, Society of Biomedical Laboratory Scientists, India
  3. 2017: Early Career Research Award, SERB, DST-India. 
  4. 2016: Postdoc of the Month Award, PostDoc Journal: Journal of Postdoctoral Research, USA. 
  5. 2016: Scholar-in-Training Award, AACR, The Function of Tumor Microenvironment in Cancer Progression Conference, San Diego, USA.
  6. 2015: K-INBRE Postdoctoral Award, National Institute of General Medical Sciences, National Institute of Health (NIH), USA.
  7. 2011: 8th EBSA European Biophysics Congress Bursaries Award, European Biophysical Societies Association, Italy.
  8. 2011: Young Scientist Award, International Academy of Physical Science, Allahabad, India. 
  9. 2009: Brains in Competition Award, Institute of Advance Studies, University of Bologna, Italy. 
  10. 2008: Indo-Italian Government Scholarship (Ministry of Human Resource and Development, India).

Grants:

  1. 2022-2025: “Analysis of the relationship between gallbladder cancer, arsenic intake, and living-environmental factors - a case in Bihar, India”, Indo-Japan, Government of Japan, Rs 100 lakh (Co-PI): Ongoing
  2. 2021-2024: “Repurposing of drugs and validation of lead compounds against main protease and RNA dependent RNA polymerase of SARS-CoV-2”, BRICS-DST, Rs 74 lakh (PI & Coordinator): Ongoing
  3. 2020-2023: “Assessment of Female reproductive health and child health risks in Arsenic Exposed population of Bihar”, ICMR New Delhi, Rs ~ 1 Crore. (Co-PI): Ongoing
  4. 2018-2021: “Understanding the Metabolic Cross-Talk between Head and Neck Squamous Cell Carcinoma and Tumor Associated Fibroblasts”, SERB-Department of Science and Technology, Government of India, Rs ~35 Lakhs. (PI): Completed
  5. 2015-2016: “Role of Tumor-Associated Fibroblasts in Head and Neck Cancer Metabolism” National Institute of General Medical Sciences, National Institute of Health, USA (P20GM103418), $25,000. (PI): Completed

Scholarly Activities

Prof. Dhruv Kumar, has a rich portfolio of scholarly activities spanning teaching, research, and academic contributions. He actively engages in designing and instructing courses at various academic levels, including undergraduate (UG), postgraduate (PG), and doctoral (PhD) programs, covering specialized areas such as Cancer Biology, Stem Cell Biology, Molecular Medicine, and Bioinformatics. Prof. Kumar's research endeavors have resulted in numerous publications in high-impact journals, including Cancer Research, Cancer Letters, Molecular Cancer, Oncogenesis, and Nature Scientific Reports. He has received recognition on both national and international platforms, garnering awards such as the Senior Scientist Award from the Society of Biomedical Laboratory Scientists, India, the Scholar-in-Training Award from the American Association for Cancer Research (AACR), USA, and the K-INBRE Postdoctoral Award from the National Institute of Health (NIH), USA. Additionally, his active involvement in government-funded projects and mentorship of PhD students in the fields of Cancer and Infertility reflects his commitment to advancing knowledge and nurturing the next generation of researchers. Prof. Kumar's scholarly activities exemplify a holistic approach to academia, seamlessly integrating teaching, research, and mentorship.

His selected publications are as below:

2023

  1. Agrawal, K.; Asthana, S.; Kumar, D. Role of Oxidative Stress in Metabolic Reprogramming of Brain Cancer. Cancers 2023, 15, 4920. https://doi.org/10.3390/cancers15204920. (Impact Factor: 5.2)
  2. Maurya, S., Raj, S., Bhoi, N.R., Mani, N., Rathi, B. and Kumar, D., 2023. Morphological analysis of metabolically dysregulated spermatozoa using Artificial Intelligence based approach. Journal of Integrated Science and Technology, 11(4), pp.569-569. (Impact Factor: 1.14)
  3. Raj, S. and Kumar, D., 2023. Early epigenetic markers for precision medicine. Progress in molecular biology and translational science, 198, pp.153-164. (Impact Factor: 4.0)
  4. Kumar, A., Ali, M., Raj, V., Kumari, A., Rachamalla, M., Niyogi, S., Kumar, D., Sharma, A., Saxena, A., Panjawani, G. and Jain, P., 2023. Arsenic causing gallbladder cancer disease in Bihar. Scientific Reports, 13(1), p.4259. (Impact Factor: 4.9)
  5. Goel, M., Mishra, M.K. and Kumar, D., 2023. Recent advances in Targeted Radionuclide therapy for Cancer treatment. Chemical Biology Letters, 10(3), pp.544-544. (Impact Factor: 6.1)
  6. Bhattacharjee, R., Prabhakar, N., Kumar, L., Bhattacharjee, A., Kar, S., Malik, S., Kumar, D., Ruokolainen, J., Negi, A., Jha, N.K. and Kesari, K.K., 2023. Crosstalk between long noncoding RNA and microRNA in Cancer. Cellular Oncology, pp.1-24. (Impact Factor: 6.6)
  7. Kumar, A., Kumar, K., Ali, M., Raj, V., Srivastava, A., Kumar, M., Niraj, P.K., Kumar, M., Kumar, R., Kumar, D. and Bishwapriya, A., 2023. Severe Disease Burden and the Mitigation Strategy in the Arsenic-Exposed Population of Kaliprasad Village in Bhagalpur District of Bihar, India. Biological trace element research, pp.1-17. (Impact Factor: 4.0)
  8. Arfin, S.; Kumar, D.; Lomagno, A.; Mauri, P.L.; Di Silvestre, D. Differentially Expressed Genes, miRNAs and Network Models: A Strategy to Shed Light on Molecular Interactions Driving HNSCC Tumorigenesis. Cancers 2023, 15, 4420. https://doi.org/10.3390/cancers15174420 (Impact Factor: 5.2)
  9. Arfin S, Agrawal K, Maurya S, Asthana S, Di Silvestre D, Kumar D. Lead phytochemicals and marine compounds against ceruloplasmin in cancer targeting. Journal of Biomolecular Structure and Dynamics. 2023 Oct 18. (Impact Factor: 5.2)
  10. Agrawal K, Chakraborty P, Dewanjee S, Arfin S, Das SS, Dey A, Moustafa M, Mishra PC, Jafari SM, Jha NK, Jha SK, Kumar D. Neuropharmacological interventions of quercetin and its derivatives in neurological and psychological disorders. Neurosci Biobehav Rev. 2023 Jan;144:104955. doi: 10.1016/j.neubiorev.2022.104955. Epub 2022 Nov 14. PMID: 36395983. (Impact Factor: 9.0)
  11. Agrawal K, Chauhan S, Kumar D. Expression analysis and regulation of GLI and its correlation with stemness and metabolic alteration in human brain tumor. 3 Biotech. 2023 Jan;13(1):10. doi: 10.1007/s13205-022-03419-5. Epub 2022 Dec 15. PMID: 36532860; PMCID: PMC9755437. (Impact Factor: 2.9)
  12. Chakraborty P, Dey A, Gopalakrishnan AV, Swati K, Ojha S, Prakash A, Kumar D, Ambasta RK, Jha NK, Jha SK, Dewanjee S. Glutamatergic neurotransmission: A potential pharmacotherapeutic target for the treatment of cognitive disorders. Ageing Res Rev. 2023 Mar;85:101838. doi: 10.1016/j.arr.2022.101838. Epub 2023 Jan 5. PMID: 36610558. (Impact Factor: 11.7)
  13. Raj, S., Rathi, B., Mehra, P., Asthana, S., & Kumar, D. (2023). Deciphering the role of c-MET in Metabolic reprogramming of Head and Neck squamous cell Carcinoma via In Silico analysis. Chemical Biology Letters, 10(2), 532. Retrieved from https://pubs.thesciencein.org/journal/index.php/cbl/article/view/532 (Impact Factor: 4.4)

2022

  1. Awasthi P, Dwivedi M, Kumar D, Hasan S. Insights into intricacies of the Latent Membrane Protein-1 (LMP-1) in EBV-associated cancers. Life Sci. 2023 Jan 15;313:121261. doi: 10.1016/j.lfs.2022.121261. Epub 2022 Dec 7. PMID: 36493876. (Impact Factor: 3.3)
  2. Sharma S, Tyagi R, Srivastava M, Rani K, Kumar D, Asthana S, Raj VS. Identification and validation of potent inhibitor of Escherichia coli DHFR from MMV pathogen box. J Biomol Struct Dyn. 2022 Jun 2:1-10. doi: 10.1080/07391102.2022.2080113. Epub ahead of print. PMID: 35652895. (Impact Factor: 3.3)
  3. Maurya S, Kesari KK, Roychoudhury S, Kolleboyina J, Jha NK, Jha SK, Sharma A, Kumar A, Rathi B, Kumar D. Metabolic Dysregulation and Sperm Motility in Male Infertility. Adv Exp Med Biol. 2022;1358:257-273. doi: 10.1007/978-3-030-89340-8_12. PMID: 35641874. (Impact Factor: 2.6)
  4. Das S, Roychoudhury S, Dey A, Jha NK, Kumar D, Roychoudhury S, Slama P, Kesari KK. Bacteriospermia and Male Infertility: Role of Oxidative Stress. Adv Exp Med Biol. 2022;1358:141-163. doi: 10.1007/978-3-030-89340-8_7. PMID: 35641869. (Impact Factor: 2.6)
  5. Arfin, S. .; Mani, N. .; Rathi, B.; Kumar, D. In Silico Analysis of Ceruloplasmin Alteration in Oral Squamous Cell Carcinoma. Chem Biol Lett 2022, 9, 342. (Impact Factor: 4.4)
  6. Jha NK, Arfin S, Jha SK, Kar R, Dey A, Kumar D. et al. Re-establishing the comprehension of phytomedicine and nanomedicine in inflammation-mediated cancer signaling Semin Cancer Biol. 2022 Feb 23:S1044-579X(22)00049-9. https://doi.org/10.1016/j.semcancer.2022.02.022. (Impact Factor: 17)
  7. Raj S, Kesari KK, Kumar A, Rathi B, Sharma A, Gupta PK, Jha SK, Jha NK, Slama P, Roychoudhury S, Kumar D. Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer. Molecular Cancer (BMC-Springer Nature). 2022. 26;21(1):31. https://doi.org/10.1186/s12943-022-01503-1 (Impact Factor: 41.4): Corresponding Author
  8. Pritam P, Deka R, Kumar D. et al.. Antioxidants in Alzheimer’s Disease: Current Therapeutic Significance and Future Prospects. Biology-MDPI. 2022. 11(2), 212. https://doi.org/10.3390/biology11020212 (Impact Factor: 5.0)
  9. Kumar, A. Kumar D. et al..Assessment of disease burden in the arsenic exposed population of Chapar village of Samastipur district, Bihar, India, and related mitigation initiative. Environmental Science and Pollution Research. https://doi.org/10.1007/s11356-021-18207-6 (Impact Factor: 4.3)

2021

  1. Upadhyay C. Kumar D. et al.. Synthesis of the new analogs of morpholine and their antiplasmodial evaluation against the human malaria parasite Plasmodium falciparum. New Journal of Chemistry. 2021. https://doi.org/10.1039/D1NJ04198C (Impact Factor: 3.4)
  2. Singh A, Singh AK, Giri R, Kumar D, Sharma R, Valis M, Kuca K, Garg N. The role of microRNA-21 in the onset and progression of cancer. Future Med Chem. 2021 Nov;13(21): 1885-1906. https://doi.org/10.4155/fmc-2021-0096. (Impact Factor: 3.9)
  3. Jeyaraman Madhan ,Muthu Sathish , Kumar D. et al. “Total Stromal Fraction (TSF) - Fortified Adipose Tissue-Derived Stem Cells Source: An Emerging Regenerative Realm Against COVID-19 Induced Pulmonary Compromise”, Coronaviruses 2021; e080921196287. https://doi.org/10.2174/2666796702666210908151708. (Impact Factor: 0.0)
  4. Asif Ali, Saleheen Bano, Kumar D. et al. (2021) Effect of cellulose nanocrystals on chitosan/PVA/nano β-TCP composite scaffold for bone tissue engineering application, Journal of Biomaterials Science, Polymer Edition, https://doi.org/10.1080/09205063.2021.1973709. (Impact Factor: 3.5)
  5. Mehreen Aftab, Maryam Ghufran, Kumar D. et al., In silico analysis of the role of hsa-miR-155-5p in cervical cancer, Chem. Biol. Lett. 2021, 8(3), 94-105. (Impact Factor: 4.4) : Corresponding Author
  6. Usman, M.B., Bhardwaj, S., Roychoudhury, S. Kumar D. et al.. Immunotherapy for Alzheimer’s Disease: Current Scenario and Future Perspectives. J Prev Alzheimers Dis 8, 534–551 (2021). https://doi.org/10.14283/jpad.2021.52 (Impact Factor: 4.4)
  7. Sharma, P.P., Bansal, M., Sethi, A., Pena, L., Kumar D. et al., 2021. Computational methods directed towards drug repurposing for COVID-19: advantages and limitations. RSC Advances, 11(57), pp.36181-36198. https://doi.org/10.1039/D1RA05320E (Impact Factor: 3.3)
  8. Goyal, K.; Goel, H.; Baranwal, P.; Tewary, A.; Kumar D. et al.. Immunological Mechanisms of Vaccine-Induced Protection against SARS-CoV-2 in Humans. Immuno 2021, 1, 442-456. https://doi.org/10.3390/immuno1040032 (Impact Factor: 0.0)
  9. Sharma A, Kumar D, Dahiya K, Hawthorne S, Jha SK, Jha NK, Nand P, Girgis S, Raj S, Srivastava R, Goswami VK, Gregoriou Y, El-Zahaby SA, Ojha S, Dureja H, Gupta G, Singh S, Chellappan DK, Dua K. Advances in pulmonary drug targeting microbial biofilms in respiratory diseases. Nanomedicine (Lond). 2021 Aug 5. delivery https://doi.org/10.2217/nnm-2021-0057. (Impact Factor: 5.3): : Corresponding Author
  10. Jeyaraman M, Muthu S, Bapat A, Kumar D. et al.. Bracing NK cell based therapy to relegate pulmonary inflammation in COVID-19. Heliyon. 2021 Jul;7(7):e07635. https://doi.org/10.1016/j.heliyon.2021.e07635. (Impact Factor: 1.8)
  11. Sharma A, Hawthorne S, Jha SK, Jha NK, Kumar D, Girgis S, Goswami VK, Gupta G, Singh S, Dureja H, Chellappan DK, Dua K. Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDAMB231 human breast cancer cells. Nanomedicine (Lond). 2021 Aug;16(20):1763-1773. https://doi.org/10.2217/nnm-2021-0066. (Impact Factor: 5.3)
  12. Chandel V, Maru S, Kumar A, Kumar A, Sharma A, Rathi B, Kumar D. Role of monocarboxylate transporters in head and neck squamous cell carcinoma. Life Sciences. 2021, 5;279:119709. https://doi.org/10.1016/j.lfs.2021.119709. (Impact Factor: 3.6) : Corresponding Author
  13. Raj S, Kumar A, Kumar D. Regulation of Glycolysis in Head and Neck Cancer. Adv Exp Med Biol. 2021;1280:219-230. https://doi.org/10.1007/978-3-030-51652-9_15. (Impact Factor: 2.4) : Corresponding Author
  14. Vaishali Chandel, Garima Tripathi, Seema A. Nayar, Brijesh Rathi, Abhijeet Kumar & Dhruv Kumar (2021) In silico identification and validation of triarylchromones as potential inhibitor against main protease of severe acute respiratory syndrome coronavirus 2, Journal of Biomolecular Structure and Dynamics, https://doi.org/10.1080/07391102.2021.1918255. (Impact Factor: 3.2) : Corresponding Author
  15. Rashmi Tyagi, Mitul Srivastava, Baldeep Singh, Shingini Sharma, Ramendra Pati Pandey, Shailendra Asthana, Dhruv Kumar & V. Samuel Raj (2021) Identification and validation of potent Mycobacterial proteasome inhibitor from Enamine library, Journal of Biomolecular Structure and Dynamics, https://doi.org/10.1080/07391102.2021.1914173. (Impact Factor: 3.2) : Corresponding Author
  16. Mathur, A., Raj, S., Jha, N.K. et al. Mutational heterogeneity in spike glycoproteins of severe acute respiratory syndrome coronavirus 2. 3 Biotech 11, 236 (2021). https://doi.org/10.1007/s13205-021-02791-y. (Impact Factor: 2.2) : Corresponding Author
  17. Arfin, S.; Jha, N.K.; Jha, S.K.; Kesari, K.K.; Ruokolainen, J.; Roychoudhury, S.; Rathi, B.; Kumar, D. Oxidative Stress in Cancer Cell Metabolism. Antioxidants 2021, 10, 642. https://doi.org/10.3390/antiox10050642. (Impact Factor: 5) : Corresponding Author
  18. Kumar A, Kumar R, Rahman MS, Ali M, Kumar R, Nupur N, Gaurav A, Raj V, Anand G, Niraj PK, Kumar N, Srivastava A, Biswapriya A, Chand GB, Kumar D, Rashmi T, Kumar S, Sakamoto M, Ghosh AK. Assessment of arsenic exposure in the population of Sabalpur village of Saran District of Bihar with mitigation approach. Environ Sci Pollut Res Int. 2021 Apr 11. https://doi.org/10.1007/s11356-021-13521-5 (Impact Factor: 4.3)
  19. Kumar, A., Rahman, M.S., Ali, M. et al. Assessment of arsenic exposure and its mitigation intervention in severely exposed population of Buxar district of Bihar, India. Environ. Health Sci. (2021). https://doi.org/10.1007/s13530-021-00086-6 (Impact Factor: .76)
  20. Chandel V., et al. 2021. In silico identification of potential inhibitor for TP53-induced glycolysis and apoptosis regulator in head and neck squamous cell carcinoma. 3Biotech. 11(3):117. https://doi.org/10.1007/s13205-021-02665-3 (Impact Factor: 2.2) : Corresponding Author

2020

  1. Kumar A., et al. 2020. Arsenic exposure causing cancer in the Indo - Gangetic Plain - A 2000 cancer patients’ cross-sectional design. Scientific Reports. 11, 2376 (2021). https://doi.org/10.1038/s41598-021-81579-9. (Impact Factor: 4.1)
  2. Roychoudhury S., et al. 2020. Viral pathogenesis of SARS-CoV-2 infection and male reproductive health: Myth or fact? Open Biology. 11(1): 200347, https://doi.org/10.1098/rsob.200347 (Impact Factor: 4.9)
  3. Jha N K., et al. 2020. Evidence of Coronavirus (CoV) Pathogenesis and Emerging Pathogen SARS‑CoV‑2 in the Nervous System: A Review on Neurological Impairments and Manifestations. Journal of Molecular Neuroscience. https://doi.org/10.1007/s12031-020-01767-6. (Impact Factor: 2.8)
  4. Ali A., et al. 2020. Comparative analysis of TiO2 and Ag nanoparticles on xylan/chitosan conjugate matrix for wound healing application. International Journal of Polymeric Materials and Polymeric Biomaterials. https://doi.org/10.1080/00914037.2020.1838519 (Impact Factor: 1.9)
  5. Kumar D., et al. 2020. Stem Cell Based Preclinical Drug Development and Toxicity Prediction. Current Pharmaceutical Design. https://doi.org/10.2174/1381612826666201019104712 (Impact Factor: 2.4) : Corresponding Author
  6. Tyagi R., et al. 2020. Development of potential proteasome inhibitors against Mycobacterium tuberculosis. Journal of Biomolecular Structure & Dynamics. https://doi.org/10.1080/07391102.2020.1835722 (Impact Factor: 3.2) : Corresponding Author
  7. Narula S, Tandon S, Kumar D et al. 2020. Human kidney stone matrix proteins alleviate hyperoxaluria induced renal stress by targeting cell-crystal interactions. Life Sciences. https://doi.org/10.1016/j.lfs.2020.118498 (Impact Factor: 3.6)
  8. Satyam R, Jha NK, Kar R et al. 2020. Deciphering the SSR incidences across viral members of Coronaviridae family. Chemico-Biological Interactions. https://doi.org/10.1016/j.cbi.2020.109226 (Impact Factor: 3.6)
  9. Chandel V, Raj S, Rathi B, Choudhary R, Kumar D. 2020. Structure-based drug repurposing for targeting Nsp9 replicase and spike proteins of severe acute respiratory syndrome coronavirus 2. Journal of Biomolecular Structure & Dynamics. https://doi.org/10.1080/07391102.2020.1811773 (Impact Factor: 3.2) : Corresponding Author
  10. Manish D., Vijay T., Kumar D., et al. 2020. Structural and Morphological Characterization of CdS Nanoparticles, Current Physical Chemistry. https://doi.org/10.2174/1877946810999200730222025 (Impact Factor: 1.6)
  11. Raj S, Chandel V, et al. 2020 Molecular mechanisms of interplay between autophagy and metabolism in cancer, Life Sciences. https://doi.org/10.1016/j.lfs.2020.118184 (Impact Factor: 3.6) : Corresponding Author
  12. Chandel V, Raj S, et al. 2020. Metabolic regulation in HPV associated head and neck squamous cell carcinoma, Life Sciences. https://doi.org/10.1016/j.lfs.2020.118236 (Impact Factor: 3.6) : Corresponding Author
  13. Chandel V, Kumar D. 2020. Targeting Signalling Cross-Talk between Cancer Cells and Cancer Associate Fibroblast through Monocarboxylate Transporters in Head and Neck Cancer,Anti-Cancer Agents in Medicinal Chemistry: Bentham Science Publishers, https://doi.org/10.2174/1871520620666200721135230 (Impact Factor: 2.04) : Corresponding Author
  14. Kumar S, Sharma PP, Shankar U, Kumar D et al. 2020. Discovery of New Hydroxyethylamine Analogs against 3CL pro Protein Target of SARS-CoV-2: Molecular Docking, Molecular Dynamics Simulation, and Structure-Activity Relationship Studies. J Chem Inf Model. https://doi.org/10.1021/acs.jcim.0c00326 (Impact Factor: 4.5)
  15. Pandey V, Tripathi G, Kumar D et al. 2020. Novel 3,4-diarylpyrazole as prospective anti-cancerous agents, Helion, https://doi.org/10.1016/j.heliyon.2020.e04397 (Impact Factor: 1.6) : Corresponding Author
  16. Chandel V, Raj S, Rathi B, Kumar D. 2020. In silico identification of potent FDA approved drugs against Coronavirus COVID-19 main protease: A drug repurposing approach. Chemical Biology Letters. 7(3), 166‐175. (Impact Factor: 4.4) : Corresponding Author
  17. Chandel V, Raj S, Srivastava A, Kumar D. 2020. In-silico interactions of active Phytochemicals with c-MYC EGFR and ERBB2 oncoproteins. Chemical Biology Letters. 7(1), 47‐54. (Impact Factor: 4.4) : Corresponding Author
  18. Raj S, Chandel V, Rathi B, Kumar D. 2020. Understanding the Molecular Mechanism(s) of SARS-CoV2 Infection and Propagation in Human to Discover Potential Preventive and Therapeutic Approach, Coronavirus: Bentham Science Publishers, DOI : 10.2174/2666796701999200617155013: Corresponding Author

2019

  1. Sibi Raj, Sartaj Khuranaa, Ramesh Choudhari et al. 2019. Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy. Seminars in Cancer Biology https://doi.org/10.1016/j.semcancer.2019.11.002. (Impact Factor: 15) : Corresponding Author
  2. Anukriti, Anupam D, Swati U, Pallavi S, et al. 2019. Investigation of Precise Molecular Mechanistic Action of Tobacco-Associated Carcinogen ‘NNK’ Induced Carcinogenesis: A System Biology Approach. 10(8), 564. (Impact Factor: 3.4)
  3. Asif A, Saleheen B, Satish S.P, Kumar D, Yuvraj S N, 2019. Effect of incorporation of Montmorillonite on Xylan/Chitosan conjugate scaffold. Colloids and Surfaces B: Biointerfaces 1(180) 75-82. (Impact Factor: 3.9)
  4. Vishwakarma V, New J1, Kumar D, et al., Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds. Scientific Reports. 15;8(1):12163. (Impact Factor: 4.1)
  5. Chandel V and Kumar D. 2019. The Development of Tumor Heterogeneity and Actively Targeting Therapy Resistant Subpopulations. J Embryol Stem Cell Res. 3(3): 000131: Corresponding Author

2018

  1. Kumar D, et al., 2018. Cancer-associated fibroblasts drive glycolysis in a targetable signaling loop implicated in head and neck squamous cell carcinoma progression. Cancer Research. 10.1158/0008-5472.CAN-17-1076. (Impact Factor: 12) : First Author
  2. Kumar D, et al. Perfluoro Curcumin Strongly Interacts with ABC Transporter (ABCG2): A Molecular Docking Study. J Embryol Stem Cell Res 2018, 2(2): 000113. : Corresponding Author
  3. Kumar D. 2018. Resveratrol derivative triacetyl-resveratrol interacts directly with the Gli-DNA zinc finger complex. J Cancer Res Oncobiol. Apr; 1(2):110 : Corresponding Author

2017

  1. Kumar D, et al., 2017. Development and characterization of an in vitro model for radiation-induced fibrosis,. Radiation Research. 189(3):326-336 (Impact Factor: 2.5) : First Author
  2. Kumar D, 2017. Role of tumor heterogeneity in drug resistance. Glob J Cancer Ther 3(2): 032-033. (Editorial). : Corresponding Author
  3. Kumar D, 2017. Regulation of glycolysis in head and neck squamous cell carcinoma. Postdoc Journal. 2017 Jan;5 (1):14-28. : Corresponding Author

2016

  1. Ledgerwood LG*, Kumar D*, Eterovic AK, Wick J et al., 2016. The degree of intra-tumor mutational heterogeneity varies by primary tumor sub-site. Oncotarget. Mar 28. doi: 18632/oncotarget.8448. (Impact Factor:6.4) *Equal contribution: First Author

2015

  1. Kumar D, Kandl C, Hamilton C, Shnayder Y, Tsue T, Kakarala K, Ledgerwood L, Sun X S, Huang H, Girod D, Thomas S 2015. Anti-HGF antibody ficlatuzumab mitigates tumor-associated fibroblast-facilitated head and neck cancer progression. JAMA Otolaryngology-Head & Neck Surgery. Dec 1;141 (12): 1133-9. (Impact Factor: 6.2) : First Author
  2. Kumar D, Gupta D, Shankar S, Srivastava RK. 2015. Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer. Oncotarget: 1-12. (Impact Factor:6.4) : First Author

2014

  1. Plotegher N, Kumar D, Tessari I, Brucale M, Munari F, et al. 2014. The chaperone-like protein 14-3-3eta interacts with human alpha-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing alpha-synuclein cellular toxicity. Human Molecular Genetics. 23:5615-29. (Impact Factor:5.9)
  2. Kumar D, Shankar S, Srivastava RK. 2014. Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. Cancer Letters. 343:179-89. (Impact Factor:6.4) : First Author
  3. Kumar D, Plotegher N, Bubacco L, Brucale M. 2014. Quantitative AFM morphometry of non-fibrillar α- synuclein aggregation products induced by the chaperone-like protein 14-3-3. Italian Society for Microscopical Sciences. Vol 21, No 1. DOI: 10.4081/microscopie. 2014.4998. : First Author
  4. Kumar D, Shankar S, Srivastava RK. 2014. Understanding the biological functions and therapeutic potentials of stem cells and cancer stem cells: Where are we? Journal of Cancer Stem Cell Research. 2:e1002:1-8. : First Author

2013

  1. Kumar D, Shankar S, Srivastava RK. 2013. Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms. Molecular Cancer. 1476-4598-12-171. (Impact Factor:27) : First Author
  2. Nanta R, Kumar D, Meeker D, Rodova M, Van Veldhuizen PJ, et al. 2013. NVP-LDE-225 (Erismodegib) inhibits epithelial-mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rgamma null mice by regulating Bmi-1 and microRNA-128. Oncogenesis. 2:e42. (Impact Factor:5.1)
  3. Shankar S, Kumar D, Srivastava 2013. Epigenetic modifications by dietary phytochemicals: Implications for personalized nutrition. Pharmacol Therapeut. 138:1-17. (Impact Factor:11.1)

2012

  1. Pivato M, De Franceschi G, Tosatto L, Frare E, Kumar D, et al. 2012. Covalent alpha-synuclein dimers: chemico-physical and aggregation properties. PloS one 7:e50027. (Impact Factor:3.4)
  2. Singh BN, Kumar D, Shankar S, Srivastava 2012. Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. Biochemical Pharmacology. 84:1154-63. (Impact Factor:6.1)

Conference Proceedings

  1. Tyagi, D. Kumar and V. S. Raj, 2018. "In silico identification of potential inhibitors against Mycobacterial proteasome," 2018 International Conference on Bioinformatics and Systems Biology (BSB), Allahabad, India, IEEE Xplore, pp. 193-197. (IF: 10.6)
  2. Shekhar Goyal, Surender Kr Beniwal, H S Kumar, Dhruv Kumar, B C Das. 2019. Role of Curcumin in reducing toxicity and adverse effects in locally advanced and metastatic breast cancer patients. Annals of Oncology. Volume 30, vi126 - vi127. (IF: 14)

Book Chapter

  1. Mavi, Anil Kumar, Manmohan Kumar, Amarjeet Singh, Mahendra Kumar Prajapati, Rakhi Khabiya, Saurabh Maru, and Dhruv Kumar. "Progress in Non‐Viral Delivery of Nucleic Acid: Advancement in Biomedical Technology." Integration of Biomaterials for Gene Therapy (2023): 281-322. https://doi.org/10.1002/9781394175635.ch10
  2. Mavi, Anil Kumar, Sonal Gaur, Neelesh Kumar, Avanish Kumar Shrivastav, Sankha Bhattacharya, Sateesh Belemkar, Saurabh Maru, and Dhruv Kumar. "Effective Gene Transfer with Non‐Viral Vectors." Integration of Biomaterials for Gene Therapy (2023): 183-222. https://doi.org/10.1002/9781394175635.ch7
  3. Kirti Agrawal, Malavika Saji, Dhruv Kumar, Drug Repurposing in Future Drug Discovery and Development, Book-Drug Repurposing and Computational Drug Discovery, Edition1st Edition 2023, Apple Academic Press, Pages26, eBook ISBN9781003347705, https://doi.org/10.1201/9781003347705
  4. Kumar, A., Raj, V., Ali, M., Abhinav, Rachamalla, M., Kumar, D., Kumari, A., Kumar, R., Shankar, P. and Ghosh, A., 2023. Evaluation of MOF Applications for Groundwater Arsenic Mitigation of the Middle Ganga Plains of Bihar, India. Metal Organic Frameworks for Wastewater Contaminant Removal, pp.355-373. 26 August 2023, https://doi.org/10.1002/9783527841523.ch16
  5. Saniya Arfin, Dhruv Kumar, Chapter 3 - Use of vitamins and minerals as dietary supplements for better health and cancer prevention, Editor(s): Inamuddin, Tariq Altalhi, Jorddy Neves Cruz, Nutraceuticals, Academic Press, 2023, Pages 53-97, ISBN 9780443191930, https://doi.org/10.1016/B978-0-443-19193-0.00003-4.
  6. A Santoshkumar, S Ray, S Narayanan, D Kumar, S Harihar (2023), Mitophagy in cancer and cancer stem cells: a role in metabolic reprogramming. Autophagy and Metabolism-Potential Target for Cancer Therapy 1 (1), 1-364. https://doi.org/10.1016/B978-0-323-99879-6.00009-2
  7. T Singh, AS Kharat, B Rathi, D Kumar (2023), Designing metabolic target-specific inhibitors for cancer therapy. Autophagy and Metabolism-Potential Target for Cancer Therapy 1 (1), 1-364. https://doi.org/10.1016/B978-0-323-99879-6.00011-0
  8. Sibi Raj, Manish K. Mishra, Sitaram Harihar, Ashok Kumar, Shubhadeep Roychoudhury, Arun Kumar et al. (2022). Regulation of Glucose Transporters in Cancer Progression, Book, Free Radical Biology and Environmental Toxicity, Springer Nature. https://link.springer.com/chapter/10.1007/978-3-030-83446-3_9
  9. Stephen James, Saniya Arfin, Manish K. Mishra, Arun Kumar, Niraj Kumar Jha, Saurabh Kumar Jha et al. (2022). Role of Arsenic in Carcinogenesis, Book, Free Radical Biology and Environmental Toxicity, Springer Nature. https://link.springer.com/chapter/10.1007/978-3-030-83446-3_7
  10. Raj S., Kumar A., Kumar D. (2020) Regulation of Glycolysis in Head and Neck Cancer, Book. Cancer Metabolomics, Advances in Experimental Medicine and Biology, Springer Nature. https://doi.org/10.1007/978-3-030-51652-9_15
  11. Chandel V., Kumar D. (2020) Role of Interferon in Cancer Metabolism. Innate Immunity in Health and Disease. IntechOpen. https://doi.org/10.5772/intechopen.92020
  12. Raj S, Chandel V., Maurya S, Kumar D. (2020) Role of Macrophages in Solid Tumor Metabolism. Macrophages. IntechOpen. https://doi.org/10.5772/intechopen.93182
  13. Maurya S, Chandel V, Raj S, (2020) OMICS IN CANCER: FROM DIAGNOSTICS TO THERAPEUTICS. Recent Trends in ‘Computational Omics'. ISBN: 978-1-53617-941-5
  14. Raj S., Chandel V., Kumar D. (2020) Cancer Cell Metabolism: Solid Tumor Versus Nonsolid Tumor. In: Kumar D. (eds) Cancer Cell Metabolism: A Potential Target for Cancer Therapy. Springer, Singapore: https://doi.org/10.1007/978-981-15-1991-8_1
  15. Pedroza D.A. et al. (2020) Role of Autophagy in Cancer Cell Metabolism. In: Kumar D. (eds) Cancer Cell Metabolism: A Potential Target for Cancer Therapy. Springer, Singapore: https://doi.org/10.1007/978-981-15-1991-8_6
  16. Chandel V., Raj S., Choudhari R., Kumar D. (2020) Role of c-Met/HGF Axis in Altered Cancer Metabolism. In: Kumar D. (eds) Cancer Cell Metabolism: A Potential Target for Cancer Therapy. Springer, Singapore: https://doi.org/10.1007/978-981-15-1991-8_7
  17. Kumar D., Sharma-Walia N., Kapoor S., Tandon S. (2020) Antibody-Targeted Nanoparticles for Cancer Treatment. In: Saxena S., Khurana S. (eds) NanoBioMedicine. Springer, Singapore: https://doi.org/10.1007/978-981-32-9898-9_3
  18. Singh B., Malhotra H., Kumar D., Mujtaba S.F., Upadhyay A.K. (2019) Understanding Cellular and Molecular Events of Skin Aging and Cancer: An Integrative Perspective. In: Dwivedi A., Agarwal N., Ray L., Tripathi A. (eds) Skin Aging & Cancer. Springer, Singapore: https://doi.org/10.1007/978-981-13-2541-0_2
  19. Tripathi M.K., Sinha J., Srivastava S.K., Kumar D. (2019) Bioinformatics in Skin Cancer: A System Biology Approach to Understanding the Molecular Mechanisms and It’s Regulations. In: Dwivedi A., Agarwal N., Ray L., Tripathi A. (eds) Skin Aging & Cancer. Springer, Singapore: https://doi.org/10.1007/978-981-13-2541-0_10
  20. Khurana S., Bose S., Kumar D. (2019) Applications of Microarray-Based Technologies in Identifying Disease-Associated Single Nucleotide Variations. In: Tripathi V., Kumar P., Tripathi P., Kishore A., Kamle M. (eds) Microbial Genomics in Sustainable Agroecosystems. Springer, Singapore: https://doi.org/10.1007/978-981-32-9860-6_4
  21. Singh P., Tiwari D., Mishra M., Kumar D. (2019) Molecular Mechanisms of Heavy Metal Toxicity in Cancer Progression. In: Kesari K. (eds) Networking of Mutagens in Environmental Toxicology. Environmental Science and Engineering. Springer, Cham: https://doi.org/10.1007/978-3-319-96511-6_3
  22. Chandel V., Seth G., Shukla P., Kumar D. (2019) Role of Radiation in DNA Damage and Radiation Induced Cancer. In: Kesari K. (eds) Networking of Mutagens in Environmental Toxicology. Environmental Science and Engineering. Springer, Cham: https://doi.org/10.1007/978-3-319-96511-6_1
  23. Dhruv Kumar, Sharmila Shankar, Rakesh Srivastava. Challenges in stem cells and translational research (Book chapter). Lost in translational and clinical research. World Scientific Publication, 2014. ISBN: 9789814489089. https://doi.org/10.1142/9789814489072_0020
  24. Dhruv kumar and Bruno Samori. Mechanochemistry: Coupling mechanical forces and chemical reactions (Book chapter). Molecular Manipulation with Atomic Force Microscopy (Book), CRC Press, 2011, ISBN: 9781439809662.
  25. Dwijendra Gupta, Dhruv Kumar, Manish Dwivedi, Vijay Tripathi, Pratibha Phadke-Gupta and Surya Pratap Singh. Nanophosphors-Nanogold immunoconjugates in Isolation of Biomembranes and in Drug Delivery (Book chapter). Recent Advances in Nanomedicine (Book), VBRI Press, 2011, ISBN: 9788192006803.

Book

  1. Dhruv Kumar, Shailendra Asthana Autophagy and Metabolism Potential Target for Cancer Therapy 1st Edition - August 6, 2022 Paperback ISBN: 9780323998796 9 7 8 - 0 - 3 2 3 - 9 9 8 7 9 - 6 eBook ISBN: 9780323999458
  2. Akhileshwar Srivastava, Dhruv Kumar, Divya Singh, Rajesh Singh, Xenobiotics in Chemical Carcinogenesis:Translational Aspects in Toxicology, Elsevier, ISBN: 9780323905602
  3. Dhruv kumar. Cancer Cell Metabolism: A Potential Target for Cancer Therapy. Springer Nature. 2020, ISBN: 9789811519901.
  4. Dhruv kumar, Marco Brucale and Bruno Samori. Amyloidogenic Proceses of Intrinsically Disordered Proteins: Understanding the Aggregation Process of Intrinsically Unstructured Proteins Related to Neurodegenerative Diseases. Lambert Academic Publishing, 2014, ISBN:
  5. Dhruv kumar. Insilico analysis of Docking between HIV-1 PR and derivatives of CUI (Docking between HIV- 1 proteases and cyclic urea inhibitors: A step towards drug designing against AIDS). Lambert Academic Publishing, 2011, ISBN:

Contact

dhruv.kumar@ddn.upes.ac.in